Figure 5: miR-205 promotes OC tumorigenesis in vivo. | Scientific Reports

Figure 5: miR-205 promotes OC tumorigenesis in vivo.

From: Upregulation of MiR-205 transcriptionally suppresses SMAD4 and PTEN and contributes to human ovarian cancer progression

Figure 5

(A) Representative pictures of animals at different time points between 0 week and 8 weeks (from left to right) after inoculation with HO-8910 cells. Pictures were taken using an IVIS imaging system with i.p. injection of 100 mg/kg of D-luciferin. Color bars represented tumor cell intensity from low (blue) to high (red). (B) Luciferase activities of peritoneal tumors were measured every two weeks. The mice group that stably overexpressing miR-205 expressed significantly higher luciferase luminescence activities. (C) all the mice were sacrificed at the end of 8 weeks and the number of peritoneal implants were counted. Overexpression of miR-205 significantly promoted tumor dissemination. (D) SMAD4 and PTEN mRNA expression were significantly reduced in the miR-205 overexpression group compared with the control group. All the error bars indicate ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001.

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