Figure 3: Compound C impaired mitochondrial function and blunted melatonin-induced suppression on mitochondrial oxidative damage in diabetic myocardium. | Scientific Reports

Figure 3: Compound C impaired mitochondrial function and blunted melatonin-induced suppression on mitochondrial oxidative damage in diabetic myocardium.

From: Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling

Figure 3

The mitochondrial oxidative stress markers and OXPHOS complex subunits expression were detected after 3 hours of reperfusion. (a) Mitochondrial SOD activity. (b) Mitochondrial MDA content. (c) Mitochondrial H2O2 formation. (d) Mitochondrial ATP content. (e) Representative blots of mitochondrial OXPHOS complex subunits. The depicted data are the means ± SEM, n = 6/group. ##P < 0.01/#P < 0.05 vs the T1D + Sham group, $$P < 0.01/$P < 0.05 vs the T1D + MI/R + V group, %%P < 0.01/%P < 0.05 vs the T1D + MI/R + Mel group. T1D, type 1 diabetes. Mel, melatonin. CC, Compound C. V, vehicle.

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