Figure 6: CIRP increases lipid peroxidation and iNOS in ALI. | Scientific Reports

Figure 6: CIRP increases lipid peroxidation and iNOS in ALI.

From: Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress

Figure 6

At 20 h after CLP, the lung levels of (A) 4-HNE (WB) and (B) iNOS (RT-PCR) were elevated in septic WT mice (*P < 0.05 vs. sham WT mice) and were significantly reduced in septic CIRP KO mice (#P < 0.05 vs. septic WT mice). The dotted lines on the WB reflect the groups shown in the histogram below. Histograms show data normalized for β-actin and relative to expression values in sham WT mice. Data are expressed as last square mean ± SEM. Sample sizes: 4-HNE, sham WT = 4, CLP WT = 6, sham CIRP KO = 4, CLP CIRP KO = 7; iNOS, WT = 2, CLP WT = 3, sham CIRP KO = 3, CLP CIRP KO = 4.

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