Figure 5: Paracrine effect of SOD3 on TPC1 cancer cell growth. | Scientific Reports

Figure 5: Paracrine effect of SOD3 on TPC1 cancer cell growth.

From: Extracellular Superoxide Dismutase Expression in Papillary Thyroid Cancer Mesenchymal Stem/Stromal Cells Modulates Cancer Cell Growth and Migration

Figure 5

(A,B) TPC1 cell growth in Thyroid MSC and PTC MSC co-cultures suggested significantly decreased TPC1 DNA replication in the Thyroid MSC culture and significantly increased DNA replication in the PTC MSC co-culture. (C) SOD3 expression in Thyroid MSCs and Thyroid MSCs transduced with SOD3 lentivirus. (D) SOD3 expression in PTC MSCs and PTC MSCs transduced with RNAi SOD3 lentivirus. (E,F) TPC1 DNA replication in Thyroid MSCs and Thyroid MSCs transduced with SOD3 lentivirus suggested increased SOD3-driven TPC1 growth. (G,H) RNA interference of SOD3 in PTC MSCs suggested decreased TPC1 DNA replication correlated with decreased SOD3 expression. (I,J) FGF9 and BMP2 gene expression analysis suggested increased SOD3-driven expression in Thyroid MSCs transduced with SOD3 lentivirus and decreased growth factor expression in PTC MSCs transduced with RNAi SOD3 lentivirus compared to controls. The p-values (*p < 0.05, **p < 0.01, ***p < 0.001) were determined by two-tail independent samples t-tests.

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