Figure 1: ChA induces cancer cell death and suppresses monocyte migration.
From: Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy
(A,B) MTT assay after incubation with ChA at the indicated concentrations or staurosporine (stsp, 3 μM) of (A) MDA-MB-231 and LNCaP for 48 h or of (B) human monocytes, for the indicated periods (24, 48 or 72 h). (C) Monocyte migration in Boyden chambers. Monocytes (upper chamber) were pre-incubated with test compounds or vehicle (0.1% DMSO) and exposed to MCP-1 (lower chamber) or left untreated for 2 h. Then, the number of migrated monocytes in the lower chamber was evaluated by ATP determination using CellTiter-Glo Luminescent Cell Viability Assay. Data are expressed as percentage of vehicle control (A,B) or as relative light units (RLU) (C), means + SEM; n = 3; *p < 0.05, **p < 0.01, ***p < 0.001 vs vehicle control.
