Table 1 Pressure Patterns at Baseline and Response To Meal.

From: Intraluminal pressure patterns in the human colon assessed by high-resolution manometry

 

Chronic Constipation (n = 15)

Controls (n = 14)

 

Baseline

Meal

Baseline

Meal

Simultaneous Pressure Waves (SPWs)

Occurrence (/30 min)

10.3 ± 7.7 (15)

13.9 ± 10.3 15)

14.7 ± 11.1 (14)

18.7 ± 17.2 (14)

Maximum frequency (/min)

1.3 ± 0.4 (11)

1.7 ± 0.7 (11)

1.4 ± 0.6 (11)

1.9 ± 0.7 (11)*

Average Pressure duration (s)

15.2 ± 5.4 (14)

14.4 ± 5.4 (13)

15.5 ± 3.5 (13)

13.7 ± 2.7 (13)

Propagation distance (cm)

33.8 ± 3.0 (14)

29.6 ± 6.4 (13)**

32.3 ± 6.5 (13)

29.8 ± 7.1 (13)

Average amplitude (mmHg)

14.2 ± 5.6 (14)

12.5 ± 5.4 (13)

14.6 ± 6.7 (14)

14.6 ± 11.1 (14)

Antegrade Pressure waves (APWs)

Occurrence (/30 min)

0.4 ± 0.8 (15)

1.5 ± 3.0 (15)

0.9 ± 1.7 (13)

1.6 ± 2.6 (14)

Maximum frequency (/min)

(0)

1.6 ± 1.3 (2)

2.0 (1)

2.2 ± 1.0 (3)

Average Pressure duration (s)

15.3 ± 3.5 (4)

17.8 ± 3.4 (6)

16.1 ± 7.3 (4)

14.1 ± 4.5 (7)

Propagation distance (cm)

21.3 ± 10.8 (4)

26.4 ± 11.2 (6)

29.3 ± 6.2 (5)

30.2 ± 6.3 (8)

Average amplitude (mmHg)

19.6 ± 22.4 (4)

22.0 ± 10.3 (6)

20.5 ± 9.2 (5)

18.6 ± 8.8 (8)

Retrograde Pressure Waves (RPWs)

Occurrence (/30 min)

0.1 ± 0.3 (15)

0.7 ± 1.6(15)

0.6 ± 1.9 (14)

0.7 ± 1.4 (14)

Maximum frequency (/min)

(0)

(0)

0.4 (1)

(0)

Average Pressure duration (s)

15.0 (1)

11.7 ± 4.1 (4)

21.9 ± 7.2 (2)

16.0 ± 5.3 (5)

Propagation distance (cm)

18.0 (1)

19.9 ± 8.3 (4)

26.0 ± 14.1(2)

24.9 ± 10.6 (5)

Average amplitude (mmHg)

12.0 (1)

26.6 ± 9.1 (4)

15.8 ± 14.3 (3)

17.6 ± 7.5 (6)

Isolated Pressure Transients

Maximum amplitude (mmHg)

132.7 ± 53.8 (15)

138.4 ± 44.9 (15)

113.4 ± 51.7 (14)

108.8 ± 47.1 (13)

Percentage of sensors involved

36.4 ± 15.0 (15)

39.3 ± 17.2 (15)

37.6 ± 15.2 (14)

39.0 ± 15.2 (14)

Percentage of time involved

70.1 ± 18.1 (15)

68.6 ± 14.3 (15)

69.4 ± 16.4 (13)

62.7 ± 19.9 (13)

Percentage with amplitude < 50 mmHg

97.6 ± 8.6 (15)

99.3 ± 1.5 (15)

99.97 ± 0.1 (14)

99.6 ± 1.4 (14)

Percentage with amplitude 50–100 mmHg

49.7 ± 22.5 (15)

55.0 ± 23.8 (15)

37.8 ± 30.3 (14)

32.3 ± 22.6 (14)#

Percentage with amplitude > 100 mmHg

21.5 ± 16.4 (15)

22.6 ± 15.7 (15)

15.6 ± 13.5 (14)

12.3 ± 12.1 (14)

High amplitude pressure waves (HAPWs)

Occurrence (%)

1 (7.1%) (15)

2 (14.3%) (15)

0 (0%) (14)

2 (14.3%) (14)

Synchronized haustral pressure waves

Occurrence (%)

1 (7.1%) (15)

9 (64.2%) 15)***

1 (7.7%) (14)

4 (30.8%) (14)

  1. Values are expressed as mean ± SD.
  2. * P = 0.027 (t = −2.6, df = 9), **P = 0.024 (t = 2.6, df = 11), before and after meal, same subject group (paired samples t test). #P = 0.025 (B = −15.4, 95% CI −2.1 to −28.8) for post meal in constipation vs post meal in control (Multiple linear regression, adjusted for baseline values). ***P = 0.008 before and after meal, using McNemar’s test, same subject group. No statistical analysis was performed when n =< 5. Synchronized haustral pressure waves always alternated with segmental haustral activity.