Table 1 Gene Ontology of top DMRs associated with Genes.
GO Term | Number of Genes | p-value |
|---|---|---|
Hypermethylation (831 Genes) | ||
Cell Communication | 266 | 1.96E-04 |
Signal Transduction | 235 | 3.63E-02 |
Metal ion binding | 207 | 3.22E-02 |
Signaling | 180 | 1.45E-05 |
Nervous system development | 164 | 1.39E-13 |
Localization | 145 | 1.05E-03 |
H3K27me3 | 106 | 4.69E-48 |
Neuron Generation | 104 | 4.50E-07 |
SUZ12 Targets | 100 | 6.30E-46 |
Cell-cell signaling | 80 | 2.35E-04 |
H3K4me3 and H3K27me3 | 73 | 7.26E-41 |
Sequence-specific DNA binding | 69 | 4.35E-02 |
PRC2 Targets | 63 | 3.77E-29 |
Neurogenesis | 60 | 9.44E-05 |
Neuron Differentiation | 53 | 1.16E-04 |
Neuron Projection Development | 49 | 1.44E-03 |
Hypomethylation (856 Genes) | ||
Localization | 521 | 3.83E-02 |
Cell Communication | 278 | 9.12E-05 |
Signaling | 277 | 2.67E-05 |
Nervous system development | 156 | 3.01E-09 |
Neurogenesis | 111 | 1.15E-06 |
H3K27me3 | 105 | 7.04E-46 |
Cell Movement | 89 | 7.00E-03 |
cell adhesion | 88 | 5.41E-03 |
H3K4me3 and H3K27me3 | 86 | 1.50E-32 |
SUZ12 Targets | 75 | 1.54E-25 |
Neuron Differentiation | 74 | 1.11E-04 |
Cell-cell adhesion | 64 | 3.04E-02 |
Neuron Development | 56 | 2.95E-02 |
PRC2 Targets | 52 | 7.36E-20 |
Neural Projection | 42 | 6.73E-04 |
Transcription Factor activity | 32 | 2.17E-02 |
Axon Guidance | 27 | 1.45E-03 |
