Table 3 Risk of Cardiovascular Event Predicted by Model of Established Risk Factors and New Model* in the Diabetic Cohort from the Singapore Malay Eye Study.

	⁺‘New’ Risk Category				Reclassified to Higher risk	Reclassified to Lower risk	NRI, %	P-value
	Low	Intermediate	High	Total	Reclassified to Higher risk	Reclassified to Lower risk	NRI, %	P-value
Subjects with incident CVD event
*Established Risk Category					12	9	3.49	0.512
Low	7	1	0	8
Intermediate	2	10	11	23
High	0	7	48	55
Total	9	18	59	86
Subjects with no incident CVD event
*Established Risk Category					62	146	13.48	<0.001
Low	179	26	5	210
Intermediate	89	104	31	224
High	1	56	132	189
Total	269	186	168	623
NRI, %							16.97	0.004

⁺Established risk factors include age (years), gender (male, female), HbA1c, systolic blood pressure (mmHg), total cholesterol (mmol/L), HDL cholesterol (mmol/L), current smoking (yes, no), diabetic medication (yes, no) and duration of diabetes (years).
*New risk factors include established risk factors, serum biomarkers (eGFR and hsCRP) and retinal microvascular parameters (retinal arteriolar caliber, retinal venular caliber, retinal vascular fractal dimension and presence of retinopathy).
NRI: Net reclassification improvement.
Risk Categories %.
Low 0− < 6.35.
Intermediate 6.35–13.2.
High >13.2.

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