Figure 7: Treatment with imatinib suppresses the development of fatty infiltration in the SSP muscle after denervation and tendon transection.
From: Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice
(A) Immunofluorescent images of the SSP sections stained for perilipin and with DAPI. Representative images of 3 biological replicates are shown (left panel). Bar, 100 μm. The ratio of the fatty tissue area in the SSP muscle sections is shown (right panel). Three different sections from each individual mouse were analyzed. n = 3 mice/group. ****p < 0.0001. (B) Immunofluorescent images of the SSP muscle sections stained for laminin and PDGFRα and with DAPI. Representative images of 3 biological replicates are shown (left panel). Bar, 30 μm. The number of PDGFRα-positive cells per microscopic field (214 μm × 214 μm) in the SSP muscle sections is shown (right panel). Three different sections from each individual mouse were analyzed. n = 3 mice/group. ****p < 0.0001. (C) Western blot analysis of the SSP tissues probed for PDGFRα and GAPDH. n = 2 mice/group.
