Figure 7: PrPC in the mitochondria of RM, C57BL/6, Tg44, and Tg3F4 mice.
From: Cellular prion protein is present in mitochondria of healthy mice
Representative TEM images are shown. In all mice, the majority of immunogold particles are localized within the inner mitochondrial membrane and matrix. Mice lacking PrP (PrP knockout) showed no reactivity and no immunogold staining was detected in samples stained with the anti-rabbit secondary antibody alone (No primary). Arrows indicate a concentration of immunogold particles above background. All sections were probed with the anti-PrP rabbit polyclonal antibody EP1802Y followed by an anti-rabbit secondary antibody conjugated to 6 nm colloidal gold. Scale bar = 100 nM.
