Figure 1: VACV boosted the functional avidity of CD8+ T cells primed by DNA vaccination. | Scientific Reports

Figure 1: VACV boosted the functional avidity of CD8+ T cells primed by DNA vaccination.

From: Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine

Figure 1

(A to F) DNA-VACV regimen induced higher levels of frequency (B) and functional avidity of antigen-specific T cell responses against immune dominant (C), subdominant epitopes (D) and peptide pools (E) in a C57BL/6 model using HIV-1 AE Gag-Env as antigen. The summarized EC50 of peptide concentration required for IFN-γ production are shown in (F). (G to J) VAVC induced higher levels of frequency (H) and functional avidity (I) in an OVA-based vaccine mice model. The EC50 was shown in (J).

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