Figure 4: Functional effects of dendoU inactivation in nervous system.
From: Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration
(a) dendoU mRNA qRT-PCR quantification in pan-neuronal interfered Drosophila heads (grey bar). Rp49 served as a standard. Expression levels in control flies (black bar) were set as 1. (b) Quantification of fly median lifespan. Average values were 32.07 ± 0.43d and 2.05 ± 0.01d in control (black circles) and pan-neuronal dendoU silenced flies (grey squares), respectively. The log rank test showed that the two curves were significantly different (P < 0.001). (c) Compared to control flies (panels 1, 2 and 3), pan-neuronal dendoU depleted flies showed unexpanded wings (black arrows), dimpled thorax (white arrow), unretracted ptilinum (headed black arrow), and misoriented scutellar bristles (headed white arrow).
