Figure 1: Mesencephalic and striatal DA denervation induced by bilateral 6-OHDA lesions of the SNc. | Scientific Reports

Figure 1: Mesencephalic and striatal DA denervation induced by bilateral 6-OHDA lesions of the SNc.

From: Implication of dorsostriatal D3 receptors in motivational processes: a potential target for neuropsychiatric symptoms in Parkinson’s disease

Figure 1

(A–C) Photographs of coronal sections stained for TH at mesencephalic (A) and striatal (C) levels and corresponding diagrams showing the masks used for the quantification of DA denervation in the different subregions analyzed. AP levels are indicated in mm from bregma. Scale: 2 mm. 6-OHDA: 6-hydroxydopamine. (B–D), Quantification of the loss of TH staining at mesencephalic (B) and striatal (D) levels, expressed as a percentage of the mean value obtained for sham-operated animals. Two-way ANOVAs and post-hoc analyses with the method of contrasts were used. *p < 0.05, **p < 0.01, ***p < 0.001, sham vs 6-OHDA (sham, n = 8; 6-OHDA, n = 7). AP: Anteroposterior; DLS: dorsolateral striatum; DMS: dorsomedial striatum; l-mSNc: lateral-medial substantia nigra pars compacta; VTA: ventral tegmental area.

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