Figure 3: Intracerebral infusion into the dorsal striatum of a selective D3R antagonist decreases operant sucrose self-administration. | Scientific Reports

Figure 3: Intracerebral infusion into the dorsal striatum of a selective D3R antagonist decreases operant sucrose self-administration.

From: Implication of dorsostriatal D3 receptors in motivational processes: a potential target for neuropsychiatric symptoms in Parkinson’s disease

Figure 3

(A) Diagrams showing the locations of each individual guide cannula for the animals included in behavioral experiments (n = 9). The circles represent the tips of the microinjectors, visualized on coronal sections counterstained with cresyl violet. AP levels are indicated in mm from bregma. (B) Mean ± SEM number of sucrose deliveries over 60-minute sessions. Dorsostriatal infusion of the D3R antagonist SB-277011A dose-dependently decreased instrumental performance for sucrose self-administration. One-way repeated ANOVA and post-hoc analyses with Student-Newman-Keuls test were used. *p < 0.05, **p < 0.01, vehicle vs SB-277011A (n = 9 per group). (C) Mean ± SEM number of cumulative sucrose deliveries within 2-minute bins over 60 minutes sessions. SB-277011A administration (5 μg.μl−1) specifically affected maintaining the instrumental response while no effect was seen during the first part of the procedure. Two-way repeated ANOVA and post-hoc analyses with the method of contrasts were used. *p < 0.05, **p < 0.01, vehicle vs SB-277011A (n = 9 per group). (D) Median latencies for the first active lever press (dotted bars) and individual values. SB-277011A administration did not modify the latency for the first active lever press (Friedman test). (E) Mean ± SEM number of cumulative sucrose deliveries within 2-minute bins over 60-minute operant self-administration sessions for sham vs 6-OHDA SNc-lesioned rats. Two-way ANOVAs and post-hoc analyses with the method of contrasts were used. *p < 0.05, **p < 0.01, sham (n = 7) vs 6-OHDA (n = 7). (F) Individual data showing similar profiles of early termination of instrumental activity observed after pharmacological inhibition of D3R in dorsal striatum (same rat before or after injection of vehicle vs SB-277011A, 5 μg.μl−1) or after SNc 6-OHDA lesion. Each microinjection experiment with vehicle vs SB-277011A was conducted by using a counterbalanced within-subject design. AP: Anteroposterior.

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