Figure 5: Knockdown of Snail inhibited EMT progress, migration/invasion capacities and enhanced OXA sensitivity. | Scientific Reports

Figure 5: Knockdown of Snail inhibited EMT progress, migration/invasion capacities and enhanced OXA sensitivity.

From: The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma

Figure 5

(a) qRT-PCR and Western blot confirmed decreased expression level of Snail in si-Snail groups. Knockdown of Snail caused the changes of EMT biomarkers with E-cadherin upregulation and downregulation of N-cadherin/Vimentin. (b,c) Knockdown of Snail inhibited migration and invasion capacities of HCC in wound healing assays and transwell invasion assays. si-control vs. si-Snail, p < 0.01, respectively. (d) Knockdown of Snail increased OXA sensitivity by CCK-8 assays. Cells were treated with different concentrations of OXA for 48 hrs. IC50 of OXA: si-control vs. si-Snail, p < 0.05, respectively. *p < 0.05, **p < 0.01, ***p < 0.001.

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