Figure 7: Neferine suppressed EMT so as to increased OXA sensitivity in xenograft nude mice. | Scientific Reports

Figure 7: Neferine suppressed EMT so as to increased OXA sensitivity in xenograft nude mice.

From: The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma

Figure 7

(a) The size of subcutaneous tumors in OXA and OXA + Neferine treatments were calculated by formula (mm3) = (L × W2) × 0.5. Tumor volumes: OXA + Nef vs. OXA, p < 0.05, respectively. (b) MMPs activities in the subcutaneous orthotopic tumors. Applying a Fluorescence Molecular Tomography imaging system, the mean fluorescence intensities were imaged and calculated as total MMPs fluorescence signal/fluorescence volume to represent MMPs activities. Mean fluorescence intensity: OXA + Nef vs. OXA, p < 0.01, respectively. (c) Neferine inhibited HCC EMT in vivo. mRNA expression of EMT biomarkers in HCC tumor was assessed by qRT-PCR. (d) HE and IHC staining of Ki-67, E-cadherin and Vimentin in mice tumors (×200 magnification) indicated that Neferine depressed EMT and increased OXA sensitivity in vivo. *p < 0.05, **p < 0.01.

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