Figure 6: The waveform of action potentials is disrupted in AP-2 depleted neurons.
From: Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons
(a,b) Representative images of Quasar transfected neurons ± AP-2KD with arrows indicating AIS. Scale bar = 5 μm. (c) Average traces of optically recorded action potentials from control (Black; n = 11) and AP-2KD (red; n = 13) neurons after subtraction of field stimulus, isolated by inclusion of TTX (300 nM) extracellularly, see methods. (d) Amplitude of AP waveforms recorded from soma of control (black; 0.177 ± 0.044) and AP-2KD (red; 0.0596 ± 0.016). **p < 0.01.
