Figure 8: Model of axogenesis in an early AP-2 depleted neuron.
From: Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons
Suggested model of axogenesis with and without AP-2 present. AP-2 mediated endocytosis is essential for establishing and maintaining axon elongation. Furthermore, AP-2 plays a critical role for establishing a functional AIS, the loss of which leads to impaired synaptogenesis and signal transduction.
