Figure 4: Lipoproteins and CVD events. | Scientific Reports

Figure 4: Lipoproteins and CVD events.

From: IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis

Figure 4

(A–D) Lipoproteins stratified for IL-32 promoter SNP rs4786370 and the presence or absence of an previously described CVD. Allele frequency, HDL Cholesterol, LDL Cholesterol and Total Cholesterol concentrations were determined in patients with RA from the RA1 (Radboud University Medical Center Nijmegen) and RA2 cohort (Reade center Amsterdam). Number of individuals: CC−:98(19.1%), CC+:27(24.3%), CT−:259(50.4%), CT+:49(44.1%), TT−:157(30.5%), TT+:35(31.5%). Chi-square analysis (IBM SPSS Statistics v.22) showed no significant differences in allelic distribution between the cohorts. There was a significant difference in HDLc between the individuals with the TT genotype versus TT genotype + previous CVD; p = 0.0293. Values are expressed as means ± SEM. p-values are calculated using Mann-Whitney U-test, *p < 0.05 Graphpad prism v5.03.

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