Figure 1: The potential mechanism of rhCygb on alcohol - induced liver injury. | Scientific Reports

Figure 1: The potential mechanism of rhCygb on alcohol - induced liver injury.

From: Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro

Figure 1

Kupffer cells activated by gut-derived LPS release ROS, RNS and inflammatory cytokines (e.g., TNF-α), thus give rise to oxidative stress in liver, resulting in lipid peroxidation of cellular membranes and hepatocyte injury and even DNA damage. Based on this working model, rhCygb was employed to prevent or reverse the liver injury. (Supplementary Figure 1)

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