Table 3 SNPs that had a p value of <0.05 in the Dutch replicate, with ORs in the same direction compared to GWAS.

From: Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis

Variant details

GWAS

Replication

Meta-analysis §

SNP

Chr

Location Ж

Genes **

A1

OR ‡ (95% CI)

p

OR ╤ (95% CI)

p

OR (95% CI)

p

rs269094

1

112639174

KCND3, LOC643355

C

1.67 (1.30–2.15)

5.3 × 10−5

1.28 (1.03–1.60)

0.0292

1.44 (1.22–1.70)

1.5 × 10−5

rs9591920

13

59315119

LOC105370220

T

2.16 (1.57–2.97)

2.0 × 10−6

1.41 (1.05–1.88)

0.0227

1.71 (1.38–2.12)

9.8 × 10−7

rs1537091

21

29004226

LOC105372763, LINC00113

A

1.69 (1.34–2.14)

1.3 × 10−5

1.24 (1.01–1.52)

0.0408

1.42 (1.21–1.66)

1.1 × 10−5

  1. ЖLocation refers to human genome build 37 (GRCh37/hg19) coordinates.
  2. **Corresponding locus shown for variants within genes; two nearest genes shown for intergenic SNPs.
  3. ‡OR for A1 allele under additive model in logistic regression, with sex and three principal components as covariates.
  4. ╤OR for A1 allele under additive model in logistic regression, with sex as a covariate.
  5. §Meta-analysis performed under fixed-effects model for logistic regression result files of discovery and replication data.
  6. SNP, single nucleotide polymorphism; GWAS, genome-wide association study; RSV, respiratory syncytial virus; OR, odds ratio; CI, confidence interval; Chr, chromosome.
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