Table 3 Stratified analysis of the associations of ADIPOQ polymorphsims with hypertension.
Subgroup analysis | N | T VS G | TT VS TG + GG | TT + TG VS GG | TG VS GG | TT VS GG | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | ||
rs1501299 | |||||||||||
Ethnicity | |||||||||||
Caucasians | 2 | 0.75 (0.58,0.97) | 0.694 (0.0%) | 0.77 (0.47,1.27) | 0.396 (0.0%) | 0.83 (0.71,0.98) | 0.975 (0.0%) | 0.82 (0.68,0.99) | 0.789 (0.0%) | 0.68 (0.42,1.10) | 0.445 (0.0%) |
Mongolian | 7 | 1.03 (0.92,1.15) | 0.405 (2.6%) | 1.05 (0.85,1.28) | 0.157 (35.5%) | 1.00 (0.93,1.08) | 0.807 (0.0%) | 1.00 (0.92,1.08) | 0.891 (0.0%) | 1.08 (0.87,1.34) | 0.207 (29.0%) |
Age | |||||||||||
≥40 | 5 | 1.00 (0.89,1.13) | 0.398 (1.5%) | 1.06 (0.80,1.39) | 0.105 (47.7%) | 0.99 (0.85,1.15) | 0.705 (0.0%) | 0.98 (0.84,1.15) | 0.729 (0.0%) | 1.04 (0.79,1.38) | 0.137 (42.6%) |
<40 | 3 | 0.89 (0.71,1.10) | 0.044 (67.9%) | 1.05 (0.68,1.61) | 0.114 (54.0%) | 0.77 (0.57,1.04) | 0.179 (41.8%) | 0.76 (0.55,1.05) | 0.369 (0.0%) | 0.89 (0.55,1.44) | 0.064 (63.7%) |
BMI of cases (kg/m2) | |||||||||||
≥26 | 5 | 0.91 (0.79,1.04) | 0.190 (34.8%) | 0.91 (0.67,1.23) | 0.074 (53.2%) | 0.88 (0.74,1.04) | 0.324 (14.2%) | 0.88 (0.74,1.06) | 0.360 (8.1%) | 0.84 (0.62,1.16) | 0.082 (51.7%) |
<26 | 4 | 1.07 (0.92,1.25) | 0.482 (0.0%) | 1.25 (0.90,1.75) | 0.595 (0.0%) | 1.04 (0.86,1.27) | 0.696 (0.0%) | 1.01 (0.82,1.25) | 0.874 (0.0%) | 1.24 (0.87,1.77) | 0.508 (0.0%) |
Source of controls | |||||||||||
Hospital based | 7 | 1.01 (0.90,1.13) | 0.205 (29.3%) | 1.17 (0.91,1.50) | 0.445 (0.0%) | 0.97 (0.84,1.12) | 0.299 (17.1%) | 0.94 (0.81,1.10) | 0.429 (0.0%) | 1.11 (0.85,1.45) | 0.308 (16.0%) |
Population based | 2 | 0.86 (0.69,1.07) | 0.313 (1.8%) | 0.69 (0.41,1.16) | 0.072 (69.1%) | 0.87 (0.66,1.15) | 0.738 (0.0%) | 0.93 (0.69,1.24) | 0.828 (0.0%) | 0.66 (0.39,1.14) | 0.087 (65.8%) |
Sample size | |||||||||||
Large (≥300) | 4 | 1.00 (0.89,1.14) | 0.255 (26.1%) | 1.00 (0.75,1.33) | 0.110 (50.4%) | 1.01 (0.86,1.18) | 0.650 (0.0%) | 1.01 (0.86,1.19) | 0.914 (0.0%) | 1.00 (0.67,1.48) | 0.160 (39.1%) |
Small (<300) | 5 | 0.93 (0.78,1.10) | 0.156 (39.8%) | 1.14 (0.79,1.64) | 0.224 (29.6%) | 0.82 (0.65,1.04) | 0.387 (3.5%) | 0.80 (0.62,1.02) | 0.561 (0.0%) | 1.00 (0.74,1.34) | 0.101 (51.8%) |
rs2241766 | G VS T | GG VS GT + TT | GG + GT VS TT | GT VS TT | GG VS TT | ||||||
Ethnicity | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | |
Caucasians | 2 | 1.67 (1.16,2.40) | 0.648 (0.0%) | 4.92 (1.03,23.54) | 0.915 (0.0%) | 1.46 (1.07,2.00) | 0.571 (0.0%) | 1.37 (0.99,1.90) | 0.511 (0.0%) | 5.29 (1.11,25.28) | 0.948 (0.0%) |
Mongolian | 10 | 1.13 (1.03,1.24) | 0.353 (9.7%) | 1.26 (1.06,1.50) | 0.697 (0.0%) | 1.05 (0.99,1.12) | 0.281 (17.6%) | 1.03 (0.96,1.10) | 0.244 (21.7%) | 1.25 (1.06,1.48) | 0.527 (0.0%) |
rs266729 | G VS C | GG VS GC + CC | GG + GC VS CC | GC VS CC | GG VS CC | ||||||
Ethnicity | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | OR (95%CI) | Ph (I2) | |
Caucasians | 2 | 1.13 (0.93,1.38) | 0.423 (0.0%) | 2.13 (1.28,3.54) | 0.915 (0.0%) | 0.97 (0.80,1.18) | 0.238 (28.3%) | 0.81 (0.63,1.04) | 0.125 (57.4%) | 1.87 (1.14,3.07) | 0.859 (0.0%) |
Mongolian | 3 | 1.05 (0.91,1.20) | 0.109 (54.8%) | 1.06 (0.71,1.59) | 0.204 (37.1%) | 1.04 (0.92,1.19) | 0.230 (31.9%) | 1.05 (0.91,1.21) | 0.451 (0.0%) | 1.10 (0.74,1.63) | 0.129 (51.1%) |
