Figure 4: Increased neuroblasts in the hippocampal dentate gyrus of MECP2 transgenic mice. | Scientific Reports

Figure 4: Increased neuroblasts in the hippocampal dentate gyrus of MECP2 transgenic mice.

From: Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome

Figure 4

(a) Experimental scheme for assessing new neuroblasts in the adult hippocampus. (b–e) Sample confocal images of immunostaining of DAPI, MCM2 and DCX. Arrows indicate BrdU+/DCX+ neuroblasts. Scale bar: (b–e), 20 μm. (f) The dentate gyrus of MECP2 TG mice exhibited increased BrdU+/DCX+ neuroblasts analyzed at 7 days after 4 doses of BrdU injections. (g) MECP2 TG mice had similar DG volume with WT mice. Values are Mean ± S.E.M (n = 4 animals for each genotype; **P < 0.01, ns: non-significant, student’s t-test).

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