Figure 5: FTY720 increases the amplitude of NMDAR-mediated mEPSCs. | Scientific Reports

Figure 5: FTY720 increases the amplitude of NMDAR-mediated mEPSCs.

From: Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons

Figure 5

(A) Mean NMDAR-mediated mEPSCs from control and FTY720-treated neurons (left) and corresponding representative traces (right). (B) Summary histogram showing the mean amplitudes of NMDAR-mediated mEPSCs from control and FTY720-treated neurons (number of cells: ctr = 35, FTY720 = 26; Student’s t-test, P = 0.002) (B-left); corresponding cumulative distributions of peak amplitudes from single representative cells (Kolmogorov-Smirnov test, P ≤ 0.001) (B-right). (C) Summary histogram showing mean frequencies of neurons in B-left (Mann-Whitney Rank Sum test P = 0.507). (D,E) Summary histograms and line series plots showing the block of ifenprodil on mEPSC amplitude in control (D) and FTY720-treated neurons (E) (number of cells: ctr = 14, FTY720 = 9; ctr basal vs ifenprodil: paired t-test, P = <0.001; FTY basal vs ifenprodil: paired t-test, P = 0.021) (D,E-left) and corresponding peak amplitude cumulative distributions from single representative cells (D,E-right) (ctr basal vs ifenprodil: Kolmogorov-Smirnov test, P ≤ 0.001; FTY basal vs ifenprodil: Kolmogorov-Smirnov test, P ≤ 0.001). (F) Residual NMDA mEPSC amplitude after Ifenprodil block (% residual amplitude ctr vs FTY: student t-test, P = 0.422).

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