Figure 4: Plasminogen stimulates increased IL-6 and uPA production by LFs in association with greater plasmin activity.
From: The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF
Levels of (a) plasmin activity, (b) uPA, (c) PAI-1 and (d) IL-6 in the media conditioned by LFs from IPF (n = 6) and control (n = 5–6) donors incubated with plasminogen for 24 h. *P < 0.05, **P < 0.01.
