Figure 5: uPA and PAR-1 regulate the conversion of plasminogen into plasmin and subsequent IL-6 production. | Scientific Reports

Figure 5: uPA and PAR-1 regulate the conversion of plasminogen into plasmin and subsequent IL-6 production.

From: The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF

Figure 5

(a) Levels of uPA in cultures of RNAi-transfected LFs. Data analyzed by student’s t test. (b) An immunoblot which shows PAR-1 protein knock-down in cell lysates by RNAi transfection (representative of 3 experiments). Supernatant levels of (c) plasmin activity and (d) IL-6 in cell cultures following RNAi transfection and 24 h plasminogen (15 μg/mL) incubation. *P < 0.05, **P < 0.01 (n = 3–5).

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