Figure 6: Plasmin(ogen) stimulates LF proliferation in an IL-6-dependent manner.
From: The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF
(a) Attached cell number following incubation with plasminogen (1.5–15 μg/mL) for 48 h (n = 5 control donors and n = 7 IPF donors). (b) Attached cell number following RNAi transfection and subsequent plasminogen (Plg, 15 μg/mL) or plasmin (Plm, 5 mU/mL) incubation. (c) Effect of SCH79797, a PAR-1 inhibitor, on plasmin-stimulated increases in cell number. (d) Cell number following incubation with plasmin and anti-IL-6 or control IgG (2 μg/mL) for 48 h. *P < 0.05, **P < 0.01, (n = 3–7).
