Table 1 Plasmin stimulates increased IL-6 and uPA production by LFs.

From: The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF

Plasmin (mU/mL)

IL-6 (% basal)

uPA (% basal)

1.5

5

15

1.5

5

15

Control

136 ± 10

203 ± 40*

230 ± 30*

68 ± 14

85 ± 21

330 ± 169

IPF

148 ± 27

228 ± 36*

220 ± 33*

103 ± 26

691 ± 418

1042 ± 439*^

  1. Levels of IL-6 and uPA in the culture supernatants of LFs from IPF (n = 6) and control (n = 5) donors incubated with plasmin for 24 h.*P < 0.05 compared to baseline. ^P < 0.05 compared to non-IPF at 15 mU/mL.
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