Figure 4: ASIV increases intestinal stem cell number in crypt of TNBS- challenged rat colon. | Scientific Reports

Figure 4: ASIV increases intestinal stem cell number in crypt of TNBS- challenged rat colon.

From: Astragaloside IV ameliorates 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis implicating regulation of energy metabolism

Figure 4

(A) Representative images of immunohistochemistry staining for Lgr5 (brown) of colon tissue from different groups (a1-a5). Bar = 100 μm. The area within the rectangle in each picture is enlarged and presented below correspondingly (b1-b5, Bar = 50 μm). (B) Quantification analysis of Lgr5-positive cells in different groups (N = 8). (C) Representative Western blots and statistical analysis of Lgr5 in colon tissue in different groups (N = 5). Sham: sham group; ASIV: ASIV alone group; TNBS 1D: TNBS treatment for 1 day group; TNBS 7D: TNBS treatment for 1 days followed by saline treatment for 6 days group; TNBS 7D + ASIV: TNBS treatment for 1 day followed by ASIV treatment for 6 days group. Data are mean ± SEM. *p < 0.05 vs. Sham group, #p < 0.05 vs. TNBS 7D group.

Back to article page