Figure 3: Characterization of the skin immune system of P-Sel−/− mice.
From: P-Selectin preserves immune tolerance in mice and is reduced in human cutaneous lupus
(a) Relative frequency of skin leukocyte populations of 1.5–3 month-old and >18-month-old WT and P-Sel−/− mice. (b) Percentage of IL-10+ macrophages (CD11b+), conventional dendritic cells (cDC), plasmacytoid DC (pDC) and B cells, in 1.5–3-month-old and >18-month-old WT and P-Sel−/− mice. (c) Representative dot plots of IL-10+ cDCs in >18-month-old WT and P-Sel−/− mice. (d) Percentage of IL-17+ T cells in 1.5–3-month-old and >18-month-old WT and P-Sel−/− mice. (e) Representative dot plots of IL-17+ T cells in >18-month-old WT and P-Sel−/− mice. (f) Percentage of FOXP3+ T cells in 1.5–3-month-old and >18-month-old WT and P-Sel−/− mice. (g) Representative dot plots of FOXP3+ T cells in >18-month-old WT and P-Sel−/− mice. *p < 0.05; **p < 0.01 by Student’s two tailed t test. n = 6 mice per genotype.
