Figure 3
From: Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites
Histograms represent the percentage of collagen volume fraction (panel A) in the myocardium of Vehicle-, EXP3179-, EXP3174-, L-NAME + Vehicle-, L-NAME + EXP3179- and L-NAME + EXP3174-treated rats. Representative images of myocardial tissue from one rat of each group are shown in panel B. Sections were stained with picrosirius red and collagen fibers were identified in red. Expression of procollagen type I mRNA is shown in panel C. Bars represent mean + SEM (n = 10). *P < 0.05 vs Vehicle, EXP3179 and EXP3174, †P < 0.05 vs L-NAME + Vehicle, #P < 0.05 vs Vehicle and L-NAME + Vehicle.
