Figure 5
From: Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites
Histograms represent the fold change in procollagen type I mRNA expression in HDFa fibroblasts stimulated without and with 10−4 μg/mL TGF-β1 for 24 hours, in the absence or the presence of 1, 2, 5, 10, 20 and 50 μM of EXP3179 (panel A) and EXP3174 (panel B), or incubated with the two compounds alone at 20 and 50 μM, as compared with controls cells. Bars represent mean + SEM (n = 5 to 8 experiments). *P < 0.05 vs Control, †P < 0.05 vs TGF-β1.
