Table 1 Echocardiographic Parameters.

From: Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites

Variables

Vehicle

L-NAME

+Vehicle

+EXP3179

+EXP3174

LV morphology

 RWT

0.42 ± 0.01

0.53 ± 0.02**

0.49 ± 0.02*

0.52 ± 0.01**

 LVMI, mg/g

1.32 ± 0.05

1.82 ± 0.06**

1.45 ± 0.02††

1.68 ± 0.02**†

LV systolic function

 EF, %

72.3 ± 0.83

63.1 ± 3.35*

75.6 ± 2.35†

73.5 ± 3.28†

 FS, %

43.7 ± 0.45

35.1 ± 2.34*

45.7 ± 2.14†

44.1 ± 2.70†

LV diastolic function

 E, cm/s

81.1 ± 5.19

69.4 ± 3.52*

82.8 ± 2.03†

83.1 ± 4.25†

 A, cm/s

58.2 ± 3.51

60.6 ± 1.13

62.2 ± 3.02

58.4 ± 1.53

 E/A

1.40 ± 0.06

1.19 ± 0.03*

1.35 ± 0.07†

1.43 ± 0.08†

  1. Data are expressed as mean ± SEM. LV means left ventricle; RWT, relative wall thickness; LVMI, left ventricular mass index; EF, ejection fraction; FS, fractional shortening; E, peak velocity of early transmitral inflow; A, peak velocity of late transmitral inflow. *P < 0.05 vs Vehicle; †P < 0.05 vs L-NAME + Vehicle; **P < 0.01 vs Vehicle; ††P < 0.01 vs L-NAME + Vehicle.
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