Figure 1: Profile of DNA methylation according to obesity state in adipose tissue.

Differences in the global methylation levels of the overall valid CpGs between the obese and non-obese subcutaneous adipose tissue samples (a). Global differences in the methylation levels of the 12,043 differentially methylated CpGs (DMCpGs) identified by 450-k array analysis (b). Supervised clustering of the 12,043 CpGs that were found to be differentially methylated between the obese and non-obese groups (c). P-values were computed using wilcoxon rank sum test.