Figure 2: Characteristics of the candidate differentially methylated CpGs (DMCpGs).

Genomic distributions of the differentially methylated CpG sites and their respective locations regarding the broader CpG context (a), the gene region (b) and chromosome distribution (c). Summary of the gene ontology (GO) analysis of the biological process categories for the 4,481 genes represented by the 12,043 differentially methylated CpG sites (d). *Significant differences (p < 0.05) in the distributions of differentially methylated CpG sites compared with all analyzed sites on the Infinium HumanMethylation450 BeadChip, by chi-square test.