Table 2 Relevant genes holding obesity-related differentially methylated CpGs (DMCpGs) and its association with gene expression.

From: DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: a genome-wide analysis from non-obese and obese patients

TargetID

Gene name

Function

Methylation levels (UNAV COHORT)

Expression levels (GSE15524 GEO COHORT)

Obese

Non-obese

Delta

P-value

Obese

Non-obese

Delta

P-value

Mean

SD

Mean

SD

Mean

SD

Mean

SD

cg25932599

FGFRL1

Metabolism signaling and insulin processing35; cell proliferation and differentiation37

0.24

0.08

0.36

0.05

−0.11

0.002

2.80

2.93

0.70

0.49

2.10

0.067

cg25152348

NCAPH2

Senescence39

0.34

0.13

0.44

0.04

−0.10

0.003

2.14

0.38

2.15

1.34

−0.01

0.933

cg06936779

PIP5K1A

Involved in diverse cellular events through its product the phospholipid phophatidylinositol 4.5-bi-sphosphate (PIP2)54

0.23

0.07

0.36

0.04

−0.12

<0.001

0.20

0.14

0.26

0.19

−0.06

0.683

cg22712983

PNKD

Potentially involved in the mitochondrial function43

0.57

0.07

0.46

0.07

0.12

0.002

0.17

0.06

0.38

0.06

−0.21

0.024

cg02051077

PODXL

Proadhesive molecule involved in atherosclerosis55 and tumor growth56

0.27

0.07

0.38

0.02

−0.11

0.001

0.86

0.42

0.34

0.15

0.53

0.024

cg02874908

PTPRCAP

Regulatory network of inflammation57

0.73

0.07

0.85

0.02

−0.14

<0.001

0.42

0.29

0.14

0.05

0.28

0.017

cg17858911

RSRC2

Tumor suppressor involved in cell proliferation58

0.25

0.07

0.36

0.08

−0.12

0.002

12.49

6.56

13.05

4.71

−0.57

0.940

cg0757622

SMAD3

Miscellaneous factor of adipogenesis. transdiferentiation and glucose homeostasis41

0.30

0.07

0.41

0.04

−0.11

<0.001

0.14

0.06

0.02

0.01

0.12

0.016

cg23713156

WDR45L

No items found

0.23

0.08

0.34

0.04

−0.10

0.005

0.65

0.19

0.22

0.04

0.43

0.012

  1. P value denotes statistical differences between obese and non-obese evaluated by Mann-Whitney U test.
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