Figure 1: Similar networks of brain regions were activated in the patient group and the control group while viewing positive minus neutral pictures.

There were different activation patterns while viewing negative pictures and neutral pictures in the two groups: the control group showed both increased and decreased activation patterns; however, the migraine subjects showed only increased activation. While viewing negative pictures vs. neutral pictures, the patient group showed significantly higher activation than the control group in the bilateral cerebellum anterior lobe/culmen, the bilateral lingual gyri, the bilateral precuneus and the left cuneus. (Red color represents increased activation, and green color represents decreased activation).