Table 1 Genes differentially expressed between control femur and control TBT at E12/13, resulting from unpaired significance analysis of microarrays analysis (SAMR), with ~5% false discovery rate (FDR).

From: Limb proportions show developmental plasticity in response to embryo movement

Gene Symbol

Gene Name

Fold Change

Known association with endochondral ossification

RAB10

RAB10, member RAS oncogene family

1.179574992

 

NRIP3

nuclear receptor interacting protein 3

1.242047415

 

SCUBE2

signal peptide, CUB domain, EGF-like 2

1.14502171

Regulates endochondral ossification, likely via IHH82

ACTC1

actin, alpha, cardiac muscle 1

1.502716256

 

HMGB3

high mobility group box 3

1.102570551

Closely related HMBG2 is expressed by relatively undifferentiated chondrocytes with roles in chondrocyte differentiation and articular cartilage via beta-catenin pathway85

OCM2

oncomodulin 2

1.728998125

 

BLMH

bleomycin hydrolase

1.139048505

 

BZW2

basic leucine zipper and W2 domains 2

1.085036637

 

SRL

sarcalumenin

1.316752616

 

SRP68

signal recognition particle 68 kDa

1.099992098

 

BTF3L4

basic transcription factor 3-like 4

1.148606842

Associated with chondrocyte differentiation88

IGF2BP3

insulin-like growth factor 2 mRNA binding protein 3

1.080702446

Chondrocyte differentiation89,90

Unknown

Hypothetical protein

1.368471921

 

MAP1B

microtubule-associated protein 1B

1.301912506

 

Unknown

Hypothetical protein

1.390719923

 
  1. These 17 genes were differentially expressed between control femur and control TBT at E12/13but failed to show enrichment in any specific pathway or biological function using Ingenuity IPA analysis and GOstats package in R with current GO categories (GO.db) for confirmation. Input gene lists, and related background expression gene lists were used in IPA and GO with an ~5% FDR and no-fold change filter.
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