Figure 7: Enlarged images of the peritumoral region in Case 3 from Figure 5.

The image intensity represents the measured absorbance coefficient at 795 nm, which corresponds to the amount of Hb present. S-factor values corresponding to the SO2 value of Hb are indicated according to the color bar on the right; red indicates close to 100% Hb saturation, whereas blue indicates close to 0%. (a) Peritumoral S-factor image obtained by PAM-03 before chemotherapy and (b) after chemotherapy. The amount and intensity of intratumoral signal increased after chemotherapy, and the S-factor values were low, indicating hypoxia. Yellow arrows indicate hypoxic spotty signals in the tumor.