Table 1 PPIX and griseofulvin concentrations used in the in vitro parasite growth inhibition experiments and determined in the IBSM study.

From: Griseofulvin impairs intraerythrocytic growth of Plasmodium falciparum through ferrochelatase inhibition but lacks activity in an experimental human infection study

Study (subject sample)

[PPIX] (μM)

[Griseofulvin] (μg/L)

[Griseofulvin] (μM)

PPIX:Griseofulvin molar ratio

In vitro

0.16

 

50

1:313

In vitro

0.8

 

50

1:63

In vitro

1.6 b

 

50

1:31

In vitro

4 b

 

50

1:13

IBSM (I6) a

0.08 c

767 d

2.17

1:27

IBSM (I7) a

0.12 c

747 d

2.12

1:18

  1. aPlasma sample collected on study Day 7 in IBSM Cohort 2.
  2. bComplete blockade of griseofulvin parasiticidal activity observed at these PPIX concentrations (determined in Fig. 2b).
  3. cPPIX concentrations determined by HPLC MS-MS (Supplementary Fig. S5).
  4. dPlasma griseofulvin concentration (determined in Fig. 4c).
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