Figure 5: Log10 CFU in mouse kidneys.
To determine whether immunization with hybrid phage could reduce the S. globosa levels in organs, the mice were sacrificed, and the log10 CFU was quantified in kidneys 7 days after the mice were immunized. There were significantly fewer log10 CFU in the organs of hybrid phage-immunized mice than in those that immunized with PBS (control group) and wild-type phage (mock group). There was no statistically significant difference in clearance from the kidney between the HK-SG-immunized group and recombinant phage-immunized group. Values followed by different capital letters differ significantly among the control, mock, HK-SG, and RP groups. RP: recombinant phage, MOCK: wild-type phage; HK-SG: heat-killed S. globosa.
