Table 1 Candidate tumor suppressor genes downregulated in gastric cancer tissues of patients with hepatic metastasis.
From: GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer
Symbol | GC tissue/Normal | Full name | Location | Function | H-meta/GC tissue | ||
|---|---|---|---|---|---|---|---|
Log2 | P | Log2 | P | ||||
GPR155 | −4.43 | <0.0001 | G protein-coupled receptor 155 | 2q31.1 | Multi-pass membrane protein | 0.01 | 1.0000 |
MFSD4 | −4.32 | <0.0001 | major facilitator superfamily domain containing 4 | 1q32.1 | Membrane transporter | −0.69 | 0.4659 |
HRASLS2 | −4.26 | <0.0001 | HRAS-like suppressor 2 | 11q12.3 | Metabolic enzyme | −1.38 | 0.1086 |
SLC9A4 | −3.95 | <0.0001 | solute carrier family 9, subfamily A, member 4 | 2q12.1 | Signal transducer | −0.40 | 0.6221 |
ALDH3A1 | −3.40 | <0.0001 | aldehyde dehydrogenase 3 family, member A1 | 17p11.2 | Metabolic enzyme | −0.95 | 0.3085 |
DPT | −3.22 | <0.0001 | dermatopontin | 1q12-q23 | Extracellular matrix protein | −0.12 | 0.8893 |
POU2AF1 | −2.93 | <0.0001 | POU class 2 associating factor 1 | 11q23.1 | Transcription factor | −1.07 | 0.0575 |
IRF4 | −2.92 | <0.0001 | interferon regulatory factor 4 | 6p25-p23 | Transcription factor | −0.84 | 0.2034 |
ASAH2 | −2.82 | <0.0001 | N-acylsphingosine amidohydrolase 2 | 10q11.21 | Metabolic enzyme | 0.09 | 1.0000 |
GSTA1 | −2.76 | 0.0002 | glutathione S-transferase alpha 1 | 6p12.1 | Metabolic enzyme | 1.17 | 0.0828 |
MZB1 | −2.71 | <0.0001 | marginal zone B and B1 cell-specific protein | 5q31.2 | Immunoglobulin mediator | −1.19 | 0.1480 |
LIFR | −2.59 | <0.0001 | leukemia inhibitory factor receptor alpha | 5p13-p12 | Cytokine receptor | 0.08 | 0.9059 |
AKR1B10 | −2.57 | 0.0002 | aldo-keto reductase family 1, member B10 | 7q33 | Metabolic enzyme | 0.22 | 0.8146 |
PAIP2B | −2.50 | 0.0002 | poly (A) binding protein interacting protein 2B | 2p13.3 | Transcription factor | 0.70 | 0.2801 |
PIM2 | −2.43 | <0.0001 | Pim-2 proto-oncogene, serine/threonine kinase | Xp11.23 | Protooncogene | −0.26 | 0.5942 |
GPAT3 | −2.26 | 0.0002 | glycerol-3-phosphate acyltransferase 3 | 4q21.23 | Metabolic enzyme | 1.13 | 0.0679 |
XYLT2 | −2.09 | <0.0001 | xylosyltransferase II | 17q21.33 | Metabolic enzyme | −0.15 | 0.7747 |
METTL7A | −2.09 | 0.0002 | methyltransferase like 7 A | 12q13.12 | Methyltransferase | −0.28 | 0.6188 |
FAM46C | −2.03 | <0.0001 | family with sequence similarity 46, member C | 1p12 | Translational factor | −0.28 | 0.5389 |
IL7R | −2.02 | 0.0002 | interleukin 7 receptor | 5p13 | Cytokine receptor | −0.34 | 0.5839 |
BTG2 | −1.83 | 0.0001 | BTG family, member 2 | 1q32 | Transcription factor | 0.78 | 0.1001 |
