Table 3 Predictive factors for hematogenous metastasis/recurrence in 200 patients with gastric cancer.
From: GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer
Hem/Hem-rec (−) | Hem/Hem-rec (+) | Univariate | Multivariable | |||||
|---|---|---|---|---|---|---|---|---|
Variables | HR | P | HR | 95%CI | P | |||
Age | <65 years | 73 | 6 | 1.59 | 0.352 | |||
≥65 years | 107 | 14 | ||||||
Sex | Male | 123 | 18 | 4.17 | 0.027 | 2.42 | 0.55–17.3 | 0.259 |
Female | 57 | 2 | ||||||
CEA | ≤5 ng/ml | 144 | 11 | 3.27 | 0.018 | 3.26 | 1.03–10.6 | 0.044* |
>5 ng/ml | 36 | 9 | ||||||
CA19–9 | ≤37 IU/ml | 143 | 13 | 2.08 | 0.159 | |||
>37 IU/ml | 37 | 7 | ||||||
Tumor location | Lower third | 71 | 9 | 0.8 | 0.632 | |||
Others | 109 | 11 | ||||||
Tumor size | <50 mm | 68 | 5 | 1.82 | 0.248 | |||
≥50 mm | 112 | 15 | ||||||
Macroscopic type | Borrmann type 4/5 | 35 | 1 | 4.59 | 0.07 | |||
Others | 145 | 20 | ||||||
Tumor depth | pT1-3 | 82 | 12 | 1.79 | 0.219 | |||
pT4 | 98 | 8 | ||||||
Differentiation | Differentiated | 63 | 9 | 2.27 | 0.085 | |||
Undifferentiated | 117 | 11 | ||||||
Lymphatic involvement | Absent | 25 | 1 | 3.06 | 0.212 | |||
Present | 155 | 19 | ||||||
Vessel invasion | Absent | 72 | 1 | 12.7 | <0.001 | 19.2 | 3.53–362 | <0.001* |
Present | 108 | 19 | ||||||
Infiltrative growth | Invasive | 77 | 1 | 14.2 | <0.001 | 7.79 | 1.32–150 | 0.021* |
Expansive | 103 | 19 | ||||||
Lymph node metastasis | Absent | 54 | 3 | 2.43 | 0.136 | |||
Present | 126 | 17 | ||||||
Peritoneal lavage cytology | Negative | 127 | 18 | 3.76 | 0.044 | 3.62 | 0.77–27.0 | 0.108 |
Positive | 53 | 2 | ||||||
GPR155 expression | Low | 68 | 15 | 4.94 | 0.001 | 4.24 | 1.40–14.8 | 0.010* |
High | 112 | 5 | ||||||
