Table 1 Association of PGRS (MDD, SCZ or BP) at ≤ 0.5 with total grey matter, white matter, cerebrospinal fluid, and subcortical volumes, in sample including and excluding outliers.

From: Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank

	Including outliers (N = 978)					Excluding outliers (N = 892)
	Beta: z ratio (S.D.)	t statistic	p -uncorr.	p-FDR	R²	Beta: z ratio (S.D.)	t statistic	p -uncorr	p-FDR	R²
MDD-PGRS
GM volume	0.001 (0.027)	0.049	0.961	1.000	0.000	−0.001 (0.029)	−0.051	0.959	1.000	0.000
WM volume	−0.007 (0.027)	−0.262	0.793	1.000	0.005	−0.026 (0.028)	−0.913	0.362	1.000	0.067
CSF volume	0.042 (0.030)	1.392	0.164	0.492	0.174	0.054 (0.031)	1.748	0.081	0.243	0.289
Caudate	0.026 (0.026)	0.970	0.332	1.000	0.066	0.031 (0.028)	1.119	0.264	1.000	0.099
Hippocampus	−0.002 (0.026)	−0.082	0.935	1.000	0.000	−0.003 (0.026)	−0.130	0.896	1.000	0.001
Pallidum	0.003 (0.027)	0.107	0.915	1.000	0.001	−0.013 (0.027)	−0.466	0.641	1.000	0.016
Thalamus	−0.012 (0.020)	−0.611	0.541	1.000	0.015	−0.025 (0.020)	−1.218	0.223	1.000	0.060
Amygdala	−0.000 (0.027)	−0.010	0.992	1.000	0.000	0.015 (0.027)	0.551	0.582	1.000	0.023
Nucleus accumbens	−0.019 (0.026)	−0.742	0.458	1.000	0.038	−0.030 (0.027)	−1.126	0.260	1.000	0.093
Putamen	0.007 (0.022)	0.309	0.757	1.000	0.005	−0.010 (0.023)	−0.451	0.652	1.000	0.011
SCZ-PGRS
GM volume	−0.012 (0.028)	−0.444	0.657	1.000	0.001	−0.018 (0.029)	−0.613	0.540	1.000	0.033
WM volume	0.000 (0.027)	0.032	0.974	1.000	0.000	−0.004 (0.029)	−0.147	0.883	1.000	0.002
CSF volume	0.049 (0.030)	1.616	0.106	0.319	0.236	0.063 (0.031)	2.029	0.043	0.128	0.397
Caudate	−0.003 (0.026)	−0.101	0.919	1.000	0.001	−0.016 (0.028)	−0.559	0.577	1.000	0.025
Hippocampus	−0.001 (0.025)	−0.044	0.965	1.000	0.000	0.015 (0.026)	0.558	0.577	1.000	0.021
Pallidum	−0.015 (0.027)	−0.578	0.564	1.000	0.024	−0.022 (0.027)	−0.795	0.427	1.000	0.047
Thalamus	−0.039 (0.020)	−1.929	0.054	0.378	0.149	−0.039 (0.020)	−1.947	0.052	0.363	0.155
Amygdala	0.015 (0.026)	0.558	0.577	1.000	0.022	0.025 (0.028)	0.912	0.362	1.000	0.063
Nucleus accumbens	−0.024 (0.026)	−0.924	0.356	1.000	0.058	−0.023 (0.027)	−0.843	0.400	1.000	0.053
Putamen	0.005 (0.022)	0.211	0.833	1.000	0.002	−0.016 (0.023)	−0.672	0.502	1.000	0.025
BP-PGRS
GM volume	0.003 (0.027)	0.093	0.926	1.000	0.001	−0.012 (0.029)	−0.405	0.686	1.000	0.013
WM volume	0.000 (0.026)	0.019	0.985	1.000	0.000	0.006 (0.028)	0.229	0.819	1.000	0.004
CSF volume	−0.007 (0.029)	−0.246	0.805	1.000	0.005	0.007 (0.030)	0.216	0.829	1.000	0.004
Caudate	0.017 (0.026)	0.653	0.514	1.000	0.029	0.007 (0.028)	0.245	0.806	1.000	0.005
Hippocampus	0.024 (0.025)	0.963	0.336	1.000	0.058	0.011 (0.026)	0.421	0.674	1.000	0.012
Pallidum	−0.000 (0.026)	−0.009	0.993	1.000	0.000	−0.023 (0.027)	−0.865	0.387	1.000	0.054
Thalamus	0.010 (0.020)	0.517	0.605	1.000	0.010	0.005 (0.020)	0.249	0.803	1.000	0.002
Amygdala	0.030 (0.026)	1.158	0.247	1.000	0.091	0.032 (0.027)	1.186	0.236	1.000	0.103
Nucleus accumbens	−0.008 (0.026)	−0.296	0.767	1.000	0.006	−0.017 (0.027)	−0.626	0.532	1.000	0.028
Putamen	0.025 (0.022)	1.133	0.257	1.000	0.061	0.015 (0.023)	0.659	0.510	1.000	0.023

MDD: major depressive disorder, SCZ: schizophrenia, BP: bipolar disorder, PGRS: polygenic risk scores, uncorr.: uncorrected, FDR: false discovery rate, GM: grey matter, WM: white matter, CSF: cerebrospinal fluid, S.D.: standard deviation. Controlled for age, age², gender, genotype batch and array, and 15 MDS components. Additional fixed effects for subcortical volumes include intracranial volume and side of hemisphere. R² = estimate of variance explained by PGRS in %.

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Table 1 Association of PGRS (MDD, SCZ or BP) at ≤ 0.5 with total grey matter, white matter, cerebrospinal fluid, and subcortical volumes, in sample including and excluding outliers.

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