Table 2 Association of PGRS (MDD, SCZ or BP) at p ≤ 0.5 with gFA and gFA for association, projection and thalamic WM fibers.

From: Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank

 

Including outliers (N = 816)

Excluding outliers (N = 733)

Beta: z ratio (S.D.)

t statistic

p

R2

Beta: z ratio (S.D.)

t statistic

p

R2

MDD-PGRS

 gFA

0.017 (0.036)

0.476

0.634

0.030

−0.011 (0.038)

−0.291

0.771

0.012

 gFA Association

0.037 (0.036)

1.026

0.305

0.139

0.011 (0.039)

0.296

0.767

0.013

 gFA Projection

−0.020 (0.036)

−0.560

0.576

0.041

−0.049 (0.038)

−1.297

0.195

0.244

 gFA Thalamic

0.002 (0.037)

−0.043

0.966

0.000

−0.025 (0.039)

−0.650

0.516

0.063

SCZ-PGRS

 gFA

−0.028 (0.036)

−0.768

0.443

0.078

−0.048 (0.039)

−1.237

0.216

0.230

 gFA Association

−0.020 (0.036)

−0.559

0.576

0.041

−0.040 (0.039)

−1.034

0.302

0.161

 gFA Projection

−0.034 (0.036)

−0.947

0.344

0.116

−0.036 (0.038)

−0.947

0.344

0.132

 gFA Thalamic

−0.032 (0.037)

0.885

0.376

0.105

−0.059 (0.039)

−1.521

0.129

0.348

BP-PGRS

 gFA

−0.013 (0.036)

−0.367

0.714

0.017

−0.014 (0.038)

−0.370

0.711

0.019

 gFA Association

−0.016 (0.036)

−0.442

0.659

0.025

−0.017 (0.038)

−0.445

0.657

0.028

 gFA Projection

−0.023 (0.035)

−0.665

0.506

0.055

−0.014 (0.037)

−0.369

0.712

0.019

 gFA Thalamic

−0.000 (0.036)

0.0223

0.982

0.000

−0.008 (0.038)

−0.214

0.831

0.008

  1. FA: fractional anisotropy, WM: white matter, g: general component, MDD: major depressive disorder, SCZ: schizophrenia, BP: bipolar disorder, PGRS: polygenic risk scores, S.D.: standard deviation. Controlled for age, age2 and gender, genotype batch and array, and 15 MDS components. R2 = estimate of variance explained by PGRS in %.
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