Table 3 Association of PGRS (MDD, SCZ or BP) at p ≤ 0.5 with gMD and gMD for association, projection and thalamic WM fibers.

From: Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank

 

Including outliers (N = 816)

Excluding outliers (N = 733)

Beta: z ratio (S.D.)

t statistic

p

R2

Beta: z ratio (S.D.)

t statistic

p

R2

MDD-PGRS

 gMD

−0.047 (0.035)

−1.340

0.181

0.224

−0.028 (0.037)

−0.756

0.450

0.079

 gMD Association

−0.053 (0.036)

−1.484

0.138

0.281

−0.030 (0.038)

−0.810

0.418

0.093

 gMD Projection

−0.053 (0.037)

−1.417

0.157

0.277

−0.042 (0.039)

−1.075

0.283

0.179

 gMD Thalamic

−0.031 (0.034)

−0.907

0.365

0.094

−0.017 (0.035)

−0.479

0.632

0.029

SCZ-PGRS

 gMD

−0.018 (0.035)

−0.503

0.615

0.031

0.001 (0.037)

0.019

0.985

0.000

 gMD Association

−0.006 (0.036)

−0.179

0.858

0.004

0.005 (0.038)

0.121

0.903

0.002

 gMD Projection

−0.035 (0.037)

−0.951

0.342

0.124

−0.021 (0.040)

−0.517

0.606

0.042

 gMD Thalamic

−0.026 (0.034)

−0.777

0.438

0.068

0.003 (0.036)

0.084

0.933

0.001

BP-PGRS

 gMD

0.014 (0.034)

0.408

0.684

0.020

0.031 (0.036)

0.865

0.387

0.099

 gMD Association

0.017 (0.035)

0.500

0.617

0.030

0.032 (0.037)

0.874

0.383

0.104

 gMD Projection

0.003 (0.036)

0.082

0.935

0.000

−0.009 (0.039)

0.232

0.817

0.008

 gFMDThalamic

0.011 (0.033)

0.328

0.743

0.012

0.032 (0.035)

0.933

0.351

0.104

  1. MD: mean diffusivity, WM: white matter, g: general factor, MDD: major depressive disorder, SCZ: schizophrenia, BP: bipolar disorder, PGRS: polygenic risk scores, S.D.: standard deviation. Controlled for age, age2 and gender, genotype batch and array, and 15 MDS components. R2 = estimate of variance explained by PGRS in %.
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