Figure 6: Manhattan plot of pfsSNVs enriched in patients with specific cancer types. | Scientific Reports

Figure 6: Manhattan plot of pfsSNVs enriched in patients with specific cancer types.

From: Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids

Figure 6

X-axis indicates chromosome from 1 to 23 and X, Y in different colors. Each dot in the figure represents a pfsSNV with –log10 (p-value) calculated from a binomial test. Cutoff was set as -log10 (5e-8). A total number of 77 pfsSNVs are statistically significant in specific cancer type. [L] and [G] indicate loss of PTM/active/binding site and gain of PTM/active/binding site respectively. As marked in the figure, [L]NRAS-61-Binding Site and [G]PIK3CA-545/542-Phosphorylation significantly associate with multiple cancer type.

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