Table 4 Top 20 pfsSNVs based on the number of associated cancer type count (TP53 excluded).
Gene Name | UnprotKB ID | Variation | Functional Site | Cancer Type Count |
|---|---|---|---|---|
NRAS | P01111 | Q61K | Binding Site | 24 |
CTNNB1 | P35222 | T41A | Phosphorylation | 21 |
NRAS | P01111 | Q61R | Binding Site | 21 |
CTNNB1 | P35222 | S33C | Phosphorylation | 18 |
GNAS | P63092 | R201C | Binding Site | 16 |
GNAS | Q5JWF2 | R844C | Binding Site | 16 |
KRAS | P01116 | Q61H | Binding Site | 16 |
HRAS | P01112 | Q61L | Binding Site | 15 |
NRAS | P01111 | Q61L | Binding Site | 15 |
PTEN | P60484 | R130Q | Active Site | 15 |
CTNNB1 | P35222 | S33F | Phosphorylation | 14 |
CTNNB1 | P35222 | S37C | Phosphorylation | 14 |
CTNNB1 | P35222 | S37F | Phosphorylation | 14 |
CTNNB1 | P35222 | S45F | Phosphorylation | 14 |
GNAS | P63092 | R201H | Binding Site | 14 |
GNAS | Q5JWF2 | R844H | Binding Site | 14 |
CTNNB1 | P35222 | T41I | Phosphorylation | 13 |
CTNNB1 | P35222 | S45P | Phosphorylation | 13 |
KRAS | P01116 | Q61K | Binding Site | 13 |
KRAS | P01116 | Q61L | Binding Site | 13 |
