Figure 1: Bigelovin inhibited cell viability and proliferation in human colon cancer cells. | Scientific Reports

Figure 1: Bigelovin inhibited cell viability and proliferation in human colon cancer cells.

From: Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species

Figure 1

(a) Chemical structure of bigelovin with two α, β-unsaturated ketone moieties. (b) Bigelovin was selectively toxic to colorectal cancer cells comparing to primary normal colon cells. IC50 values from 48 h incubation in HT-29 and HCT 116 cell lines and primary normal colon cells by MTT assay. (Mean ± SD; ***p < 0.001, vs primary normal colon cells; n = 4). (c) Cell proliferation assay of two cell lines treated with bigelovin for indicated dose and time points (**p < 0.01, ***,###,&&&p < 0.001 vs. medium control at the corresponding time point; n = 3–4). HT-29 (d) and HCT 116 (e) were seeded in 100 mm dish, and after 48 h bigelovin treatment, they were reseeded and maintained for 8 or 11 days to form colonies (**p < 0.01, ***p < 0.001 vs. medium control; n = 4–5).

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