Table 3 Differences in median baseline cytokine levels and disease severity in patients with necrotising soft tissue infection.

	IL-1β	P	IL-6	P	IL-10	P	TNF-α	P
Septic shock	3.1 (1.0–8.3)	0.0008	982 (233–3475)	<0.0001	50.4 (17.8–183.7)	<0.0001	19.5 (6.0–55.5)	<0.0001
No septic shock	0.9 (0.4–5.7)	0.0008	156 (69–541)	<0.0001	14.7 (4.8–42.2)	<0.0001	5.3 (3.1–15.2)	<0.0001
β-haemolytic strep.	4.1 (0.9–12.0)	0.052	1628 (298–15611)	<0.0001	66.2 (16.1–218.5)	0.03	26.1 (7.6–140.1)	0.007
Other infections ^a	1.7 (0.6–6.9)	0.052	313 (117–1778)	<0.0001	36.5 (8.4–93.2)	0.03	11.5 (3.5–30.0)	0.007
RRT ^b	4.9 (1.3–11.9)	0.02	2649 (284–12942)	<0.0001	71.6 (11.6–243.3)	0.03	48.4 (9.1–174.9)	<0.001
No RRT	1.7 (0.6–5.7)	0.02	373 (129–1618)	<0.0001	35.3 (9.4–87.8)	0.03	11.2 (3.7–28.0)	<0.001
Amputation ^b	3.0 (1.3–11.5)	0.12	2019 (364–5799)	0.02	79.2 (39.0–330.9)	0.0008	33.8 (5.2–107.6)	0.04
No amputation	1.8 (0.6–7.2)	0.12	420 (140–1952)	0.02	33.7 (8.8–95.6)	0.0008	12.5 (4.3–35.1)	0.04
NSTI	2.3 (0.7–7.3)	<0.0001	539 (156–2484)	<0.0001	38.8 (10.0–115.4)	<0.0001	15.2 (4.3–49.8)	<0.0001
Surgical controls	0.0 (0.0–0.7)	<0.0001	0.0 (0.0–2.4)	<0.0001	1.2 (0.2–8.3)	<0.0001	0.8 (0.0–17.8)	<0.0001

Strep., streptococcus infection; RRT, renal replacement therapy; NSTI, necrotising soft tissue infection. ^aAll other types of microorganisms than monomicrobial β-haemolytic strep. infection. ^bWithin the first 7 days of admission.

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